Tony the Murderer

Piloting: Want to get Lonnie Ritter, Switchblade 2 and leather jacket out as soon as you can. Switchblade 2 is basically your weapon for the entirety of the campaign where as lonnie ritter and leather jacket together basically make you invincible with endless soak.

Upgrades to get off the ground:

-Switchblade 2 and Reliable

These should be your starting upgrades with in the thick of it. This already puts tony as a pretty dangerous combatant out the gate, attacking basically at a base fight of 9.

Next Upgrades: The second reliable, two evidences.

You're now basically at full build from a melee standpoint and Tony is going to be able to wreck house easily on both monsters and the game, basically with an ammo-less weapon and guaranteed cluing. Everything after this is just fluff to help you find all the above easier.

Next: Easy mark and three aces to thin the deck out. Ever vigilant to compress playing his assets. Charisma and then Delilah.

Now Tony doesn't even have to attack enemies to kill them. He's also now attacking at a might of 10.

Icing: Sure Gamble x2, Hard Knocks, Snipe and then Sawed Off Shotgun.

Note that the sawed off shotgun is a single handed weapon and so you can still keep your knife out for the majority of combat. The Sawed off exists solely to combine with a double or nothing, vicious, sniped sure gamble boosted to at least +6 the boss's fight value with Hard Knocks to effectively guarantee a OHK on all but the most hearty bosses (pulling in a total of 16 damage in one hit).