There is a certain official scenario where, on the back of the last card in the agenda deck, it just says "all investigators take 100 horror (cannot be cancelled or ignored)" as a means to eliminate everyone and end the scenario.
Imagine that Stella and Roland are doing this scenario and that Roland (who is In the Thick of It) has an Enchanted Armor in play when this last agenda card is flipped. Roland assigns all 100 horror to Enchanted Armor and then has to "Test Willpower (100), if failed, discard Enchanted Armor and reassign the 100 horror", but Stella commits Neither Rain Nor Snow to this test. What happens? Roland should survive, right? Does scenario just continue forever, without an agenda deck?